HomeSearch by AntimicrobialRoxithromycin
Antimicrobial Name: Roxithromycin
CAS Number: 80214-83-1
Type of Antibiotic: Macrolides
Origin: Semi-synthetic
Functional Category: Antibiotic
Molecular Weight: 837.05
Mechanism of Action: Roxithromycin prevents bacteria from growing, by interfering with their protein synthesis. Roxithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides. Roxithromycin has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.
Chemical Formula:

C41H76N2O15

Solubility:

0.0189 mg/L at 25°C

Melting point:

119 - 120 °C

Resistance Genes:

mexc-Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

mexd-Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

oprj-Resistance-nodulation-cell division transporter system. Multidrug resistance efflux pump.

Comments:

Roxithromycin is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Roxithromycin is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.