HomeSearch by AntimicrobialStreptomycin
Antimicrobial Name: Streptomycin
CAS Number: 57-92-1
Type of Antibiotic: Aminoglycosides
Origin: Fermentation
Functional Category: Antibiotic
Molecular Weight: 581.574
Mechanism of Action: Aminoglycosides like Streptomycin “irreversibly” bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.
Chemical Formula:

C21H39N7O12

Melting point:

>20 g/l in water

Resistance Genes:

strA: streptomycin resistance protein A

strB: streptomycin resistance protein B

sph: streptomycin resistance protein

aad9: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

aad9ib: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ant3ia: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

ant6ia: Aminoglycoside O-nucleotidylyltransferase, which modifies aminoglycosides by adenylylation.

aph33ia: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

aph33ib: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

aph6ia: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

aph6ib: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

aph6ic: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

aph6id: Aminoglycoside O-phosphotransferase, which modifies aminoglycosides by phosphorylation.

norm: Multi antimicrobial extrusion (MATE) efflux family protein. Multidrug resistance efflux pump.

str: Streptomycin resistance protein.

Comments:

Streptomycin (Streptomycin) is an antibiotic drug, the first of a class of drugs called aminoglycosides to be discovered, and was the first antibiotic remedy for tuberculosis. It is derived from the actinobacterium Streptomyces griseus. Streptomycin is a bactericidal antibiotic. Streptomycin cannot be given orally, but must be administered by regular intramuscular injections. An adverse effect of this medicine is ototoxicity, which can cause ear damage.