HomeSearch by AntimicrobialJosamycin
Antimicrobial Name: Josamycin
CAS Number: 16846-24-5
Type of Antibiotic: Macrolides
Functional Category: Antibiotic
Molecular Weight: 827.995
Mechanism of Action: The mechanism of action of macrolides such as Josamycin is via inhibition of bacterial protein biosynthesis by binding reversibly to the subunit 50S of the bacterial ribosome, thereby inhibiting translocation of peptidyl tRNA. This action is mainly bacteriostatic, but can also be bactericidal in high concentrations. Macrolides tend to accumulate within leukocytes, and are therefore actually transported into the site of infection.
Chemical Formula:

C42H69NO15    

Solubility:

Very sol in methanol, ethanol, acetone, chloroform, ethyl acetate, dioxane, acidic water. Sol in butanol, ether, CCl4, benzene, toluene. Practically insol in water, petr ether, ligroin, n-hexane.

Melting point:

130 - 133 °C

Comments:

Josamycin is a macrolide antibiotic. It is synthesized from strains of Streptomyces narbonensis var. josamyceticus var. nova