HomeSearch by AntimicrobialMetronidazole (Flagyl)
Antimicrobial Name: Metronidazole (Flagyl)
CAS Number: 443-48-1
Type of Antibiotic: Other Antibiotics
Functional Category: Antibiotic
Molecular Weight: 171.154
Mechanism of Action: Unionized metronidazole is selective for anaerobic bacteria due to their ability to intracellularly reduce metronidazole to its active form. This reduced metronidazole then disrupts DNA’s helical structure, inhibiting bacterial nucleic acid synthesis and resulting in bacterial cell death.
Chemical Formula:

C6H9N3O3

Solubility:

1.0 g/100 ml at 20 °C in water

0.5 g/100 ml at 20 °C in ethanol

<0.05 g/100 ml at 20 °C in ether

<0.05 g/100 ml at 20 °C in chloroform

Sparingly sol in DMF.

Sol in dil acids.

 

 

Melting point:

158 - 160°C

 

Comments:

Metronidazole (Flagyl) is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa. Metronidazole is an antibiotic, amebicide, and antiprotozoal. It is the drug of choice for first episodes of mild-to-moderate Clostridium difficile infection.