HomeSearch by AntimicrobialNovobiocin (Albamycin)
Antimicrobial Name: Novobiocin (Albamycin)
CAS Number: 303-81-1
Type of Antibiotic: Quinolones->Others
Origin: Chemical/Synthetic
Functional Category: Antibiotic
Molecular Weight: 612.624
Mechanism of Action: Novobiocin (Albamycin) is an aminocoumarin. Aminocoumarins are very potent inhibitors of bacterial DNA gyrase and work by targeting the GyrB subunit of the enzyme involved in energy tranduction. Novobiocin as well as the other aminocoumarin antibiotics act as competitive inhibitors of the ATPase reaction catalysed by GyrB.
Chemical Formula:

<p>C<sub>31</sub>H<sub>36</sub>N<sub>2</sub>O<sub>11</sub></p>

Solubility:

<p>Practically insol in more acidic solns. Sol in acetone, ethyl acetate, amyl acetate, lower alcohols, pyridine.</p>

Melting point:

<p>152-156 &deg;C (dec)</p>

Comments:

<p>Novobiocin (Albamycin), also known as albamycin or cathomycin, is an aminocoumarin antibiotic that is produced by the actinomycete Streptomyces niveus, which has recently been identified as a subjective synonym for S. spheroides a member of the order Actinobacteria .</p>