| Antimicrobial Name： |
Ticarcillin/clavulanate (Timentin) |
| CAS Number： |
34787-01-4 |
| Type of Antibiotic： |
Penicillin Combinations |
| Functional Category： |
Antibiotic |
| Molecular Weight： |
384.429 |
| Appearance： |
White or pale-yellow powder |
| Mechanism of Action： |
Ticarcillin's antibiotic properties arise from its ability to prevent cross-linking of peptidoglycan during cell wall synthesis, when the bacteria tries to divide, causing cell death. Ticarcillin, like penicillin, contains a β-lactam ring that can be cleaved by β-lactamases, resulting in inactivation of the antibiotic. Those bacteria that can express β-lactamases are, therefore, resistant to β-lactam antibiotics. Due, at least in part, to the common β-lactam ring, ticarcillin can cause reactions in patients allergic to penicillin. Ticarcillin is also often paired with a β-lactamase inhibitor such as clavulanic acid. |
| Solubility： |
Highly soluble in water, but should be dissolved only immediately before use to prevent degradation. |
| Comments： |
Ticarcillin/clavulanate (Timentin) is a carboxypenicillin. It is almost invariably sold and used in combination with clavulanate as Timentin. Because it is a penicillin, it also falls within the larger class of beta-lactam antibiotics. Its main clinical use is as an injectable antibiotic for the treatment of gram-negative bacteria, in particular, Pseudomonas aeruginosa. |