| Antimicrobial Name： |
Cefazolin (Ancef, Kefzol, Zolicef) |
| CAS Number： |
25953-19-9 |
| Type of Antibiotic： |
Cephalosporins->First Generation |
| Origin： |
Semi-synthetic |
| Functional Category： |
Antibiotic |
| Molecular Weight： |
454.51 |
| Mechanism of Action： |
In vitro tests demonstrate that the bactericidal action of cephalosporins results from inhibition of cell wall synthesis. By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, it inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. |
| Chemical Formula： |
C14H14N8O4S3 |
| Solubility： |
128 µg/ml at 25℃ in water |
| Melting point： |
192-200°C |
| Comments： |
Cefazolin (Ancef, Kefzol, Zolicef), also known as cefazoline or cephazolin, is a first-generation cephalosporin antibiotic. |