HomeSearch by AntimicrobialDaptomycin + 50 μg/ml Ca++
Antimicrobial Name: Daptomycin + 50 μg/ml Ca++
Type of Antibiotic: New Antibiotics
Functional Category: Antibiotic
Mechanism of Action: Daptomycin has a distinct mechanism of action, disrupting multiple aspects of bacterial cell membrane function. It appears to bind to the membrane and cause rapid depolarization, resulting in a loss of membrane potential leading to inhibition of protein, DNA and RNA synthesis, which results in bacterial cell death.

Daptomycin is a novel lipopeptide antibiotic used in the treatment of certain infections caused by Gram-positive organisms. It is a naturally-occurring compound found in the soil saprotroph Streptomyces roseosporus. Its distinct mechanism of action means that it may be useful in treating infections caused by multi-resistant bacteria.