HomeSearch by AntimicrobialItraconazole
Antimicrobial Name: Itraconazole
CAS Number: 84625-61-6
Functional Category: Antifungal
Molecular Weight: 705.64
Mechanism of Action: Itraconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Itraconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
Chemical Formula:



Practically insol in water and dil acidic solns

 0.03 g/l at 23 °C in H2O

Melting point:

165.4 °C


Itraconazole, invented in 1984, is a triazole antifungal agent that is prescribed to patients with fungal infections.