HomeSearch by AntimicrobialLomefloxacin (Maxaquin)
Antimicrobial Name: Lomefloxacin (Maxaquin)
CAS Number: 98079-51-7
Type of Antibiotic: Quinolones->Second Generation
Origin: Chemical/Synthetic
Functional Category: Antibiotic
Molecular Weight: 351.348
Mechanism of Action: Lomefloxacin (Maxaquin) is a bactericidal fluoroquinolone agent with activity against a wide range of gram-negative and gram-positive organisms. The bactericidal action of lomefloxacin results from interference with the activity of the bacterial enzymes DNA gyrase and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase appears to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV appears to be the preferential target in gram-positive organisms. Interference with these two topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. As a result DNA replication and transcription is inhibited.
Chemical Formula:



1.03 mg/ml at 25°C in ionic strength 0.15 M NaCl

Melting point:

239 - 240.5 °C


Lomefloxacin (Maxaquin) hydrochloride is a fluoroquinolone antibiotic, used to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.