| Antimicrobial Name： |
Bambermycins (Moenomycin) |
| CAS Number： |
11015-37-5 |
| Type of Antibiotic： |
Aminoglycosides |
| Functional Category： |
Antibiotic |
| Mechanism of Action： |
Although moenomycin is not as potent against Esc. coli compared to Gram positive organisms (due to the outer-membrane barrier), its mode of action on whole cells is consistent with inhibition of cell-wall synthesis. Moenomycin causes rapid lysis of growing Esc. coli cells (van Heijenoort et al., 1987), but not stationary-phase cells. Lysis, but not killing, was inhibited by the addition ofMg#+, consistent with the functioning of the autolytic system in Esc. coli. |
| Solubility： |
Sol in water, methanol, DMF; less sol in ethanol, propanol; slightly sol in ether, ethyl acetate. Insol in benzene, chloroform. |
| Melting point： |
decompn starting at 200°C. |
| Comments： |
Bambermycins (Moenomycin) is a natural product glycolipid that inhibits the growth of a broad spectrum of Gram-positive bacteria. |