HomeSearch by AntimicrobialBambermycins (Moenomycin)
Antimicrobial Name: Bambermycins (Moenomycin)
CAS Number: 11015-37-5
Type of Antibiotic: Aminoglycosides
Functional Category: Antibiotic
Mechanism of Action: Although moenomycin is not as potent against Esc. coli compared to Gram positive organisms (due to the outer-membrane barrier), its mode of action on whole cells is consistent with inhibition of cell-wall synthesis. Moenomycin causes rapid lysis of growing Esc. coli cells (van Heijenoort et al., 1987), but not stationary-phase cells. Lysis, but not killing, was inhibited by the addition ofMg#+, consistent with the functioning of the autolytic system in Esc. coli.
Solubility:

Sol in water, methanol, DMF; less sol in ethanol, propanol; slightly sol in ether, ethyl acetate. Insol in benzene, chloroform.

Melting point:

decompn starting at 200°C.

Comments:

Bambermycins (Moenomycin) is a natural product glycolipid that inhibits the growth of a broad spectrum of Gram-positive bacteria.