HomeSearch by AntimicrobialNetilmicin (Netromycin)
Antimicrobial Name: Netilmicin (Netromycin)
CAS Number: 56391-56-1
Type of Antibiotic: Aminoglycosides
Origin: Fermentation
Functional Category: Antibiotic
Molecular Weight: 475.58
Mechanism of Action: Aminoglycosides like netilmicin “irreversibly” bind to specific 30S-subunit proteins and 16S rRNA. Specifically netilmicin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes, leaving the bacterium unable to synthesize proteins vital to its growth.
Chemical Formula:

C21H41N5O7

Solubility:

100 mg/mL

Resistance Genes:

aac: aminoglycoside 2'-N-acetyltransferase Aac

Comments:

Netilmicin (Netromycin) is a member of the aminoglycoside family of antibiotics. These antibiotics have the ability to kill a wide variety of bacteria. Netilmicin is not absorbed from the gut and is therefore only given by injection or infusion. It is only used in the treatment of serious infections particularly those resistant to gentamicin.