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Cethromycin (ABT-773)
Cethromycin (ABT-773)
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Microorganism
MIC50
(μg/ml)
MIC90
(μg/ml)
Range
(μg/ml)
Reference
Streptococcus pneumonia
(erythromycin-susceptible)
0.002
0.004
0.0005 - 0.03
954
Streptococcus pneumonia
(macrolide-resistant)
0.03
0.12
≤0.015 - 1
236
Streptococcus pneumonia
(macrolide-susceptible)
0.001
0.002
≤0.0005 - 0.004
1111
Streptococcus pneumonia
(macrolide-susceptible)
0.001
0.004
<0.001 - 0.008
15
Streptococcus pneumonia
(macrolide-susceptible)
0.015
0.015
≤0.015 - 0.03
236
Streptococcus pneumonia
(mef(A) + mef(E))
0.015
0.12
0.002 - 1
1113
Streptococcus pneumonia
(mef(A) + mef(E))
0.015
0.12
0.002 - 1
954
Streptococcus pneumonia
(mef(A))
0.004
0.12
≤0.002 - 1
950
Streptococcus pneumonia
(mef(A))
0.063
0.125
≤0.008 - 0.25
1111
Streptococcus pneumonia
(mef(A))
-
0.03
≤0.002 - 0.5
331
Streptococcus pneumonia
(penicillin-intermediate)
0.004
0.015
0.002 - 4
954
Streptococcus pneumonia
(penicillin-intermediate)
0.004
0.015
0.002 - 4
1113
Streptococcus pneumonia
(penicillin-intermediate)
0.008
0.03
<0.008 - 0.25
45
Streptococcus pneumonia
(penicillin-resistant)
0.004
0.03
0.002 - 8
1113
Streptococcus pneumonia
(penicillin-resistant)
0.004
0.03
0.002 - 8
954
Streptococcus pneumonia
(penicillin-resistant)
0.015
0.12
<0.008 - 0.25
45
Streptococcus pneumonia
(penicillin-susceptible)
0.004
0.008
0.0005 - 1
1113
Streptococcus pneumonia
(penicillin-susceptible)
0.004
0.008
0.0005 - 1
954
Streptococcus pneumonia
(penicillin-susceptible)
<0.008
<0.008
<0.008 - 0.5
45
Streptococcus pneumonia
(ribosomal mutants)
0.015
0.12
0.008 - 1
1113
Streptococcus pneumonia
(ribosomal mutants)
0.015
0.12
0.008 - 1
954
Streptococcus pyogenes
0.008
0.008
≤0.002 - 32
950
Streptococcus pyogenes
(C-203 + erythromycin-susceptible)
-
-
0.002 - ?
319
Streptococcus pyogenes
(constitutively erm(B))
0.008
0.03
0.002 - 2
954
Streptococcus pyogenes
(constitutively erm(B))
0.008
0.03
0.002 - 2
1113
Streptococcus pyogenes
(constitutively erm(B))
0.12
0.5
0.004 - 1
1111
Streptococcus pyogenes
(constitutively erm(B))
-
-
0.5 - 8
15
Streptococcus pyogenes
(erm(A))
0.03
0.06
≤0.015 - >=1
950
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