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Solithromycin (CEM-101 and OP-1068)
Solithromycin (CEM-101 and OP-1068)
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Microorganism
MIC50
(μg/ml)
MIC90
(μg/ml)
Range
(μg/ml)
Reference
Enterococcus avium
0.03
1
0.015 - 2
1130
Enterococcus casseliflavus
0.03
1
0.015 - 2
1130
Enterococcus durans
0.03
1
0.015 - 2
1130
Enterococcus faecalis
0.25
2
0.015 - 2
1130
Enterococcus faecalis
(vancomycin-resistant)
0.25
2
0.015 - 2
1130
Enterococcus faecalis
(vancomycin-susceptible)
0.03
2
0.015 - 2
1130
Enterococcus faecium
1
2
0.03 - 2
1130
Enterococcus faecium
(vancomycin-resistant)
2
2
0.25 - 2
1130
Enterococcus faecium
(vancomycin-susceptible)
0.25
2
0.03 - 2
1130
Enterococcus gallinarum
0.03
1
0.015 - 2
1130
Enterococcus raffinosus
0.03
1
0.015 - 2
1130
Enterococcus
spp.
0.03
1
0.015 - 2
1130
Staphylococci (coagulase-negative)
>0.06
>16
0.03 - >16
1130
Staphylococcus aureus
>0.06
>16
0.06 - >16
1130
Staphylococcus aureus
(community-associated + meticillin-resistant)
0.12
0.12
0.06 - 0.12
1130
Staphylococcus aureus
(heterogeneous + vancomycin-intermediate)
>16
>16
0.06 - >16
1130
Staphylococcus aureus
(meticillin-resistant)
>0.12
>16
0.03 - >16
1130
Staphylococcus aureus
(meticillin-susceptible)
0.06
0.12
0.03 - >16
1130
Staphylococcus aureus
(vancomycin-intermediate)
>16
>16
0.06 - >16
1130
Staphylococcus aureus
(vancomycin-resistant)
16
-
0.12 - >16
1130