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Co-trimoxazole (Trimethoprim-sulfamethoxazole, TMP-SMX)
Co-trimoxazole (Trimethoprim-sulfamethoxazole, TMP-SMX)
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Microorganism
MIC50
(μg/ml)
MIC90
(μg/ml)
Range
(μg/ml)
Reference
Streptococci (β-haemolytic + serogroup B)
≤0.25
≤0.25
≤0.25 - 0.5
462
Streptococci (β-haemolytic + serogroup C)
≤0.25
≤0.25
≤0.25 - 0.5
462
Streptococci (β-haemolytic + serogroup F)
≤0.25
≤0.25
≤0.25 - 0.5
462
Streptococci (β-haemolytic + serogroup G)
≤0.25
≤0.25
≤0.25 - 0.5
462
Streptococcus
(group A)
0.06
0.25
≤0.06 - 0.25
73
Streptococcus
(group B)
0.06
0.12
≤0.06 - 0.25
73
Streptococcus agalactiae
(Uruguay)
0.25
0.25
≤0.06 - 2
1391
Streptococcus bovis
0.5
1
≤0.25 - >2
462
Streptococcus dysgalactiae
(Uruguay)
0.12
0.25
≤0.06 - ?
1391
Streptococcus intermedius
>1
>2
≤0.5 - >2
472
Streptococcus pneumonia
0.12
4
≤0.12 - >6
499
Streptococcus pneumonia
>0.25
>2
≤0.06 - >2
108
Streptococcus pneumonia
0.25
4
≤0.25 - >=128
236
Streptococcus pneumonia
0.5
4
≤0.5 - >8
412
Streptococcus pneumonia
-
-
0.25 - 128
956
Streptococcus pneumonia
(ATCC 49619)
-
-
4 - ?
401
Streptococcus pneumonia
(erythromycin A-resistant)
2
32
0.12 - 32
499
Streptococcus pneumonia
(erythromycin A-susceptible)
0.12
4
0.12 - 32
499
Streptococcus pneumonia
(erythromycin-resistant + 2000-2001)
>=8
≥8
<0.25 - >8
369
Streptococcus pneumonia
(erythromycin-resistant + 2001-2002)
>=4
≥8
<0.25 - >8
369
Streptococcus pneumonia
(erythromycin-resistant + 2002-2003)
>=4
≥8
<0.25 - >8
369
Streptococcus pneumonia
(erythromycin-resistant + 2003-2004)
>=4
≥8
<0.25 - >8
369
Streptococcus pneumonia
(penicillin-intermediate)
<0.5
<0.5
<0.5 - >1
84
Streptococcus pneumonia
(penicillin-intermediate)
>0.5
>1
≤0.5 - >1
195
Streptococcus pneumonia
(penicillin-intermediate)
>0.5
>1
≤0.5 - >1
114
Streptococcus pneumonia
(penicillin-intermediate)
0.5
8
≤0.12 - >16
499
Streptococcus pneumonia
(penicillin-intermediate)
>2
>2
≤0.25 - >2
462
Streptococcus pneumonia
(penicillin-intermediate)
>4
>4
0.12 - >4
73
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