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Garenoxacin (T-3811, BMS-284756)
Garenoxacin (T-3811, BMS-284756)
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Microorganism
MIC50
(μg/ml)
MIC90
(μg/ml)
Range
(μg/ml)
Reference
Staphylococcus aureus
(methicillin-resistant + quinolone-susceptible)
0.015
0.03
0.008 - 0.03
268
Staphylococcus aureus
(methicillin-resistant)
2
4
0.12 - 16
1111
Staphylococcus aureus
(methicillin-susceptible + penicillin-resistant)
0.06
0.06
0.008 - 2
102
Staphylococcus aureus
(methicillin-susceptible + penicillin-susceptible)
0.06
0.06
0.015 - 0.06
102
Staphylococcus aureus
(methicillin-susceptible)
0.025
0.025
0.0125 - 0.05
17
Staphylococcus aureus
(methicillin-susceptible)
0.03
0.03
0.008 - 1
268
Staphylococcus aureus
(methicillin-susceptible)
0.03
0.06
≤0.004 - 0.12
130
Staphylococcus aureus
(methicillin-susceptible)
0.03
0.06
≤0.004 - 0.12
443
Staphylococcus aureus
(methicillin-susceptible)
0.06
0.06
0.008 - 2
1111
Staphylococcus aureus
(oxacillin-resistant + levofloxacin-resistant)
2
4
0.25 - 32
225
Staphylococcus aureus
(oxacillin-resistant)
2
2
0.03 - 4
225
Staphylococcus aureus
(oxacillin-susceptible)
0.06
0.06
0.015 - 2
225
Staphylococcus aureus
(vancomycin-intermediate)
-
-
1 - 4
225
Staphylococcus epidermidis
(methicillin-resistant)
0.03
2
0.016 - 2
1111
Staphylococcus epidermidis
(methicillin-resistant)
0.05
0.1
0.025 - 0.2
17
Staphylococcus epidermidis
(methicillin-resistant)
2
4
0.03 - 16
102
Staphylococcus epidermidis
(methicillin-susceptible)
0.03
0.03
0.03 - 0.06
1111
Staphylococcus epidermidis
(methicillin-susceptible)
0.05
0.1
0.025 - 0.78
17
Staphylococcus epidermidis
(methicillin-susceptible)
0.12
2
0.03 - 8
102
Staphylococcus epidermidis
(oxacillin-resistant)
2
32
0.06 - 32
225
Staphylococcus epidermidis
(oxacillin-susceptible)
-
-
0.06 - 4
225
Staphylococcus haemolyticus
0.06
4
0.03 - 8
225
Staphylococcus saprophyticus
0.03
0.06
0.03 - 0.06
225
Staphylococcus warneri
-
-
0.03 - 0.125
225
Stenotrophomonas maltophilia
2
4
0.25 - 8
268
Stenotrophomonas maltophilia
4
8
2 - >64
225
Streptococci (coagulase-negative + methicillin-resistant)
1
4
0.03 - 4
130
Streptococci (coagulase-negative + methicillin-susceptible)
0.06
1
0.015 - 4
130
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