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Daptomycin (Cubicin)
Daptomycin (Cubicin)
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Microorganism
MIC50
(μg/ml)
MIC90
(μg/ml)
Range
(μg/ml)
Reference
Staphylococcus pyogenes
-
-
0.015 - 0.5
1261
Staphylococcus pyogenes
(C-203)
-
-
0.06 - ?
1261
Staphylococcus saprophyticus
0.25
0.5
0.06 - 2
472
Staphylococcus sciuri
0.25
0.5
0.06 - 2
472
Staphylococcus simulans
0.25
0.5
0.06 - 2
472
Staphylococcus
spp.
0.25
0.5
0.06 - 2
472
Staphylococcus
spp.
-
-
0.25 - 2
1261
Staphylococcus
spp. (meticillin-resistant)
-
-
0.004 - 1
1261
Staphylococcus warneri
0.25
0.5
0.06 - 2
472
Staphylococcus xylosus
0.25
0.5
0.06 - 2
472
Streptococci (serogroup C)
-
-
0.03 - 0.25
1261
Streptococci (serogroup D)
1
4
0.03 - 8
472
Streptococci (serogroup G)
-
-
0.015 - 0.06
1261
Streptococci (Viridans group + penicillin-resistant)
0.5
-
≤0.12 - 1
483
Streptococci (Viridans group)
0.5
1
≤0.03 - >1
73
Streptococci (Viridans group)
-
-
0.12 - 2
1261
Streptococcus
(group A)
0.06
0.06
≤0.03 - 0.5
73
Streptococcus
(group B)
0.25
0.25
0.06 - 0.5
73
Streptococcus
(group D)
1
4
0.03 - 8
472
Streptococcus intermedius
0.25
0.5
0.06 - 2
472
Streptococcus oralis
(linezolid-resistant)
1
2
≤0.12 - 4
483
Streptococcus pneumonia
0.12
0.25
≤0.015 - 1
162
Streptococcus pneumonia
(ATCC 10813)
-
-
0.12 - ?
127
Streptococcus pneumonia
(ATCC 49619)
-
-
0.25 - ?
127
Streptococcus pneumonia
(CDC 1020)
-
-
0.25 - ?
127
Streptococcus pneumonia
(CDC 1199)
-
-
0.12 - ?
127
Streptococcus pneumonia
(CDC 1325)
-
-
0.25 - ?
127
Streptococcus pneumonia
(CDC 1396)
-
-
0.12 - ?
127
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