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Telithromycin (HMR 3647, RU-66647, Ketek)
Telithromycin (HMR 3647, RU-66647, Ketek)
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Microorganism
MIC50
(μg/ml)
MIC90
(μg/ml)
Range
(μg/ml)
Reference
Streptococcus pneumonia
(erythromycin A-susceptible)
0.008
0.016
≤0.001 - 0.12
950
Streptococcus pneumonia
(erythromycin A-susceptible)
0.015
0.06
≤0.001 - >=64
950
Streptococcus pneumonia
(erythromycin A-susceptible)
≤0.12
≤0.12
≤0.12 - ?
499
Streptococcus pneumonia
(erythromycin-intermediate)
≤0.12
≤0.12
? - ?
18
Streptococcus pneumonia
(erythromycin-resistant + 2000-2001)
0.5
1
<0.015 - 2
369
Streptococcus pneumonia
(erythromycin-resistant + 2001-2002)
0.12
0.5
<0.015 - 2
369
Streptococcus pneumonia
(erythromycin-resistant + 2002-2003)
0.25
0.5
0.015 - 2
369
Streptococcus pneumonia
(erythromycin-resistant + 2003-2004)
0.25
0.5
<0.015 - 2
369
Streptococcus pneumonia
(erythromycin-resistant)
0.03
0.12
? - ?
496
Streptococcus pneumonia
(erythromycin-resistant)
0.06
0.25
<0.008 - 128
948
Streptococcus pneumonia
(erythromycin-resistant)
0.12
0.25
? - ?
18
Streptococcus pneumonia
(erythromycin-resistant)
-
0.5
≤0.015 - 4
1105
Streptococcus pneumonia
(erythromycin-susceptible)
0.008
0.015
0.002 - 0.12
1113
Streptococcus pneumonia
(erythromycin-susceptible)
0.008
0.015
0.002 - 0.12
954
Streptococcus pneumonia
(erythromycin-susceptible)
0.008
0.015
? - ?
496
Streptococcus pneumonia
(erythromycin-susceptible)
0.008
0.016
0.004 - 0.06
1113
Streptococcus pneumonia
(erythromycin-susceptible)
0.008
0.031
≤0.008 - 0.031
502
Streptococcus pneumonia
(erythromycin-susceptible)
0.016
0.03
<0.004 - 0.13
948
Streptococcus pneumonia
(erythromycin-susceptible)
≤0.12
≤0.12
? - ?
18
Streptococcus pneumonia
(inducible + erm(A))
0.015
0.06
0.002 - 1
954
Streptococcus pneumonia
(L22 & 23S rRNA mutants)
0.06
-
0.016 - 0.5
1113
Streptococcus pneumonia
(L4 mutants)
0.06
0.125
0.06 - 0.125
1113
Streptococcus pneumonia
(levofloxacin-intermediate-resistant)
0.015
0.5
≤0.004 - 4
268
Streptococcus pneumonia
(macrolide-resistant)
0.06
0.5
≤0.015 - 2
236
Streptococcus pneumonia
(macrolide-resistant)
-
-
≤0.015 - 0.5
49
Streptococcus pneumonia
(macrolide-susceptible)
0.004
0.008
≤0.0005 - 0.015
1111
Streptococcus pneumonia
(macrolide-susceptible)
0.015
0.015
≤0.015 - 0.5
236
Streptococcus pneumonia
(mef(A) + mef(E))
0.125
0.5
0.008 - 2
1113
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